Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu<sup>+</sup>supplants entropically favoured Zn<sup>2+</sup>to form Cu<sub>4</sub><sup>+</sup>clusters under physiological conditions
Matthew R. Mehlenbacher, Rahma Elsiesy, Rabina Lakha, Rhiza Lyne E. Villones, Marina Orman, Christina L. Vizcarra, Gabriele Meloni, Dean E. Wilcox, Rachel N. Austin
Abstract
metal binding to these thiolate-rich proteins and quantitative support for, as well as molecular insight into, the role that MT-3 plays in the neuronal chemistry of copper.
Topics & Concepts
MetallothioneinMetalChemistryZincCrystallographyInorganic chemistryOrganic chemistryTrace Elements in HealthHeavy Metal Exposure and ToxicityDrug Transport and Resistance Mechanisms