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Development of pyrazole and pyrazolopyrimidine derivatives as promising anti-MRSA agents targeting penicillin-binding protein (PBP2a) and mecA gene

Ahmed Ragab, Moustafa S. Abusaif, Heba Mohammed Refat M. Selim, Omnia Karem M. Riad, Mohamed H. Helal, Abeer M. Ali, Yousry A. Ammar, Ghada E. Ahmed

2025Bioorganic Chemistry11 citationsDOI

Topics & Concepts

ChemistryCandida albicansEscherichia coliPyrazoleADMEMicrobiologyAntibacterial activityStaphylococcus aureusBiofilmAntimicrobialGeneAntibioticsQuorum sensingBiochemistryBacteriaFluconazoleSCCmecMechanism of actionEffluxAntibacterial agentCorpus albicansVirulencePotencyBiological activityClick Chemistry and ApplicationsCancer therapeutics and mechanismsSynthesis and biological activity
Development of pyrazole and pyrazolopyrimidine derivatives as promising anti-MRSA agents targeting penicillin-binding protein (PBP2a) and mecA gene | Litcius