Identification of a <i>Streptococcus parasuis</i> isolate co-harbouring the oxazolidinone resistance genes <i>cfr</i>(D) and <i>optrA</i>
Yao Zhu, Yang Qin, Štefan Schwarz, Wenlin Yang, Qiu Xu, Lingli Wang, Siguo Liu, Wanjiang Zhang
Abstract
Oxazolidinones, such as linezolid and tedizolid, represent last-resort drugs for the treatment of serious clinical infections caused by MDR Gram-positive bacteria. To date, seven different acquired oxazolidinone resistance genes have been identified, including cfr, cfr(B), cfr(C), cfr(D), cfr(E), optrA and poxtA.1 The gene cfr(D), a cfr gene variant, codes for an rRNA methyltransferase that confers a similar PhLOPSA resistance phenotype to that of Cfr.2 The gene optrA encodes an ATP-binding cassette F (ABC-F) protein, which confers resistance to both oxazolidinones and phenicols.3,4,Streptococcus parasuis, a close relative of Streptococcus suis, is a species composed of members formerly belonging to S. suis serotypes 20, 22 and 26.5,S. parasuis can be distinguished from S. suis by genetic content and biochemical features.6 In this study, we identified an S. parasuis strain of porcine origin...