Four-component synthesis of 3-aminomethylated imidazoheterocycles in EtOH under catalyst-free, oxidant-free and mild conditions
Qingwen Gui, Binbin Wang, Sha Zhu, Fulong Li, Mengxue Zhu, Min Yi, Jialing Yu, Zhilin Wu, Wei‐Min He
Abstract
The 3-aminomethylated imidazoheterocycles were efficiently synthesized in one-step <italic>via</italic> a four-component reaction of equimolar cheap and commercially available reactants at ambient temperature under catalyst-, oxidant-, base-free and mild conditions.
Topics & Concepts
CatalysisComponent (thermodynamics)ChemistryCombinatorial chemistryOrganic chemistryPhysicsThermodynamicsChemistry and Chemical EngineeringMulticomponent Synthesis of HeterocyclesSynthesis and biological activity