Regulating Androgen Receptor Function in Prostate Cancer: Exploring the Diversity of Post-Translational Modifications
Lance Edward V. Lumahan, Mazia Arif, Amy E. Whitener, Ping Yi
Abstract
Androgen receptor (AR) transcriptional activity significantly influences prostate cancer (PCa) progression. In addition to ligand stimulation, AR transcriptional activity is also influenced by a variety of post-translational modifications (PTMs). A number of oncogenes and tumor suppressors have been observed leveraging PTMs to influence AR activity. Subjectively targeting these post-translational modifiers based on their impact on PCa cell proliferation is a rapidly developing area of research. This review elucidates the modifiers, contextualizes the effects of these PTMs on AR activity, and connects these cellular interactions to the progression of PCa.
Topics & Concepts
Prostate cancerAndrogen receptorTranscriptional activityCancer researchCancerSuppressorFunction (biology)ReceptorTranslational researchBiologyStimulationTumor progressionNeuroscienceBioinformaticsMedicineCell biologyInternal medicineTranscription factorGeneticsGeneBiotechnologyProstate Cancer Treatment and ResearchEstrogen and related hormone effectsUbiquitin and proteasome pathways