USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis
Jae‐Hyun Kim, Junnosuke Nakamura, Chiharu Hamada, Takumi Taketomi, Sarasa Yano, Tomomi Okajima, Shin‐ichi Kashiwabara, Tadashi Baba, Ban Sato, Tomoki Chiba, Fuminori Tsuruta
Abstract
gene induces an impairment in motor ability with an unconventional cerebellar formation. Moreover, inhibition of the USP15-TUT1 cascade triggered mild and chronic endoplasmic reticulum (ER) stress. Therefore, our results suggest that USP15 is crucial for mRNA metabolism and maintains a healthy brain. These findings provide a possibility that disturbance of the USP15-TUT1 cascade induces chronic and mild ER stress, leading to an acceleration of the neurodegenerative phenotype.
Topics & Concepts
BiologyEndoplasmic reticulumCell biologyGene knockdownGeneBiochemistryUbiquitin and proteasome pathwaysRNA modifications and cancerEndoplasmic Reticulum Stress and Disease