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Design, synthesis, activity and molecular dynamics studies of 1,3,4-thiadiazole derivatives as selective allosteric inhibitors of SHP2 for the treatment of cancer

Wen-Shan Liu, Jifeng Zhao, Xiaojing Guo, Sheng-Ze Lu, Wei Li, Wanzhong Li, Wan-Zhong Li, Wan-Zhong Li

2023European Journal of Medicinal Chemistry21 citationsDOIOpen Access PDF

Topics & Concepts

Allosteric regulationChemistryIC50ApoptosisCancer cellWestern blotIn vitroStereochemistryProtein kinase BEnzymePhosphorylationGrowth inhibitionBiochemistryMolecular biologyCancerGeneBiologyGeneticsProtein Tyrosine PhosphatasesBioactive Compounds and Antitumor AgentsPI3K/AKT/mTOR signaling in cancer
Design, synthesis, activity and molecular dynamics studies of 1,3,4-thiadiazole derivatives as selective allosteric inhibitors of SHP2 for the treatment of cancer | Litcius