HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

Daniel B. Grabarczyk, Olga A. Petrova, Luiza Deszcz, R Kurzbauer, Paul V. Murphy, Juraj Ahel, Antonia Vogel, Rebeca Gogova, Victoria Faas, Darja Kordic, Alexander Schleiffer, Anton Meinhart, Richard Imre, Anita Lehner, Jana Neuhold, Gerd Bader, Peggy Stolt-Bergner, Jark Böttcher, B. Wolkerstorfer, Gerhard W. Fischer, Irina Grishkovskaya, David Haselbach, Dirk Kessler, Tim Clausen