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New thieno[2,3-b]pyridine-fused pyrimidin-4(3H)-ones as potential thymidylate synthase inhibitors: Synthesis, SAR, in vitro and in silico study

Sherif M. H. Sanad, Ahmed E. M. Mekky

2023Journal of Molecular Structure20 citationsDOI

Topics & Concepts

ChemistryThymidylate synthaseCytotoxicityStereochemistryPyridineIn vitroBiochemistryMedicinal chemistryFluorouracilSurgeryMedicineChemotherapyBiochemical and Molecular ResearchCancer therapeutics and mechanismsSynthesis and biological activity
New thieno[2,3-b]pyridine-fused pyrimidin-4(3H)-ones as potential thymidylate synthase inhibitors: Synthesis, SAR, in vitro and in silico study | Litcius