The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation
Kseniya Ustinova, Zora Nováková, Makoto Saito, Marat Meleshin, Jana Mikešová, Zsófia Kutil, Petra Baranová, Barbora Havlínová, Mike Schutkowski, Patrick Matthias, Cyril Bařinka
Abstract
Overall, our results reveal that recognition of substrates by HDAC6 is more complex than previously appreciated and that domains outside the tandem catalytic core are essential for proficient substrate deacetylation.
Topics & Concepts
AcetylationMicrotubuleTubulinHDAC6Domain (mathematical analysis)Cell biologyBiophysicsChemistryBiologyBiochemistryHistoneMathematicsHistone deacetylaseMathematical analysisGeneHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisSignaling Pathways in Disease