Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models
Pui Yuen Lee, Paula Olaizola, Francisco J. Caballero‐Camino, Laura Izquierdo‐Sánchez, Pedro M. Rodrigues, Álvaro Santos‐Laso, Mikel Azkargorta, Félix Elortza, Maria Luz Martínez‐Chantar, María J. Perugorria, Patricia Aspichueta, Marco Marzioni, Nicholas F. LaRusso, Luís Bujanda, Joost P.H. Drenth, Jesús M. Bañales
Topics & Concepts
SUMO proteinGene knockdownBiologyCholangiocyteCell biologyCancer researchPolycystic liver diseaseImmunoprecipitationSmall hairpin RNAProteasomeMolecular biologyApoptosisUbiquitinInternal medicineEndocrinologyBiochemistryGeneMedicineTransplantationLiver transplantationUbiquitin and proteasome pathwaysEndoplasmic Reticulum Stress and DiseaseAdenosine and Purinergic Signaling