DNA-Compatible Diversification of Indole π-Activated Alcohols via a Direct Dehydrative Coupling Strategy
Shuting Zhong, Xianfu Fang, Yiting Wang, Gong Zhang, Yangfeng Li, Yizhou Li
Abstract
Indole-based diversification is highly desired in the DNA-encoded chemical library construction. Herein, we present a general strategy for on-DNA synthesis of diverse C3-functionalized indole derivatives via indole π-activated alcohol formation followed by direct dehydrative coupling. Highly efficient bond linkages of C-C, C-N, and C-S were achieved to fuse building blocks that are widely commercially available. DNA-encoding compatibility of the method has been further demonstrated to pave an avenue for application in constructing indole-focused three-dimensional libraries.
Topics & Concepts
Indole testChemistryDNACombinatorial chemistryAlcoholStereochemistryBiochemistrySynthesis of Indole DerivativesChemical Synthesis and AnalysisClick Chemistry and Applications