The <i>cis</i> -2-Dodecenoic Acid (BDSF) Quorum Sensing System in Burkholderia cenocepacia
Mingfang Wang, Xia Li, Shihao Song, Chaoyu Cui, Lian‐Hui Zhang, Yinyue Deng
Abstract
-2-dodecenoic acid) has been recognized as a conserved DSF-type signal with specific characteristics in both signal perception and transduction from DSF signals. Here, we review the history and current progress of the research on this type of signal, especially focusing on its biosynthesis, signaling pathways, and biological functions. We also discuss and explore the huge potential of targeting this kind of QS system as a new therapeutic strategy to control bacterial infections and diseases.
Topics & Concepts
Quorum sensingBurkholderia cenocepaciaBurkholderiaMicrobiologyBiologyCell biologyBacteriaGeneticsBiofilmBacterial biofilms and quorum sensingMolecular Communication and NanonetworksVibrio bacteria research studies