<i>Lactobacillus plantarum</i> probiotic induces Nrf2-mediated antioxidant signaling and eNOS expression resulting in improvement of myocardial diastolic function
Ahmed Aboulgheit, Catherine Karbasiafshar, Zhi‐Qi Zhang, Mohamed Sabra, Guangbin Shi, Aja Tucker, Neel R. Sodha, M. Ruhul Abid, Frank W. Sellke
Abstract
Colonization of the gut microbiome with certain strains of L. Plantarum has been shown to convert caffeic acid readily available in applesauce to 4-vinyl-catechol, a potent activator of the Nrf2 antioxidant defense pathway. In this exciting study, we show that simple dietary supplementation with L. Plantarum-applesauce-mediated Nrf2 activation supports vascular function, ameliorates myocardial ischemic diastolic dysfunction, and upregulates expression of eNOS.
Topics & Concepts
EnosProbioticLactobacillus plantarumAntioxidantFunction (biology)Nitric oxideDiastoleDiastolic functionFood scienceBiologyMedicineInternal medicineCell biologyNitric oxide synthaseBacteriaBiochemistryLactic acidBlood pressureGeneticsBiochemical effects in animalsGenomics, phytochemicals, and oxidative stressSirtuins and Resveratrol in Medicine