Epidemiology of heart failure and long-term follow-up outcomes in a north-African population: Results from the NAtional TUnisian REgistry of Heart Failure (NATURE-HF)
Leïla Abid, S. Charfeddine, Ikram Kammoun, Manel Ben Halima, H. Ben Slima, Meriem Drissa, Khadija Mzoughi, Dorra Mbarek, Leila Riahi, Saoussen Antit, Afef Ben Halima, Wejdène Ouechtati, E. Allouche, M. Mechri, Chedi Youssfi, Ali Khorchani, Kaïs Rtibi, Khaled Zaouia, Rami Tlili, Sana Ouali, Faten Triki, Sonia Hamdi, Selim Boudich, M. Chebbi, M Hentati, A. Farah, Habib Triki, H. Ghardallou, H Radoui, Sofien Zayed, Fares Azaiez, Fadoua Omri, A. Zouari, Zine Ben Ali, A. Najjar, Houssem Thabet, Mouna Chaker, Samar Mohammed, Abdelhamid Ben Jmaa, Haithem Tangour, Yassine Kammoun, Mahmoud Cheikh Bouhlel, S. Azeiz, R. Gtaief, S. Mashki, Amri Amri, Hela Naanea, Raoudha Othmani, Iheb Chahbani, Houcine Zargouni, Syrine Abid, Mokded Ayari, Ines Ben Ameur, Ali Guesmi, N. Ben Halima, Habib Haouala, Wafa Fehri, Essia Boughzéla, Lilia Zakhama, Soraya Ben Youssef, Wided Nasraoui, Rachid Boujneh, Nedia Barakett, Sondos Kraïem, Hbiba Drissa, Ali Ben Khalfalah, Habib Gamra, Salem Kachboura, Yosra Majdoub, Elifa Kanoun, Faı̈ez Zannad, Sami Milouchi, Alexandre Mebaza, S. Kammoun, Sami Mourali, Karima Hezbri, Faouzi Addad
Abstract
The NATURE-HF registry was aimed to describe clinical epidemiology and 1-year outcomes of outpatients and inpatients with heart failure (HF). This is a prospective, multicenter, observational survey conducted in Tunisian Cardiology centers. A total of 2040 patients were included in the study. Of these, 1632 (80%) were outpatients with chronic HF (CHF). The mean hospital stay was 8.7 ± 8.2 days. The mortality rate during the initial hospitalization event for AHF was 7.4%. The all-cause 1-year mortality rate was 22.8% among AHF patients and 10.6% among CHF patients. Among CHF patients, the older age, diabetes, anemia, reduced EF, ischemic etiology, residual congestion and the absence of ACEI/ ARBs treatment were independent predictors of 1-year cumulative rates of rehospitalization and mortality. The female sex and the functional status were independent predictors of 1-year all-cause mortality and rehospitalization in AHF patients. This study confirmed that acute HF is still associated with a poor prognosis, while the mid-term outcomes in patients with chronic HF seems to be improved. Some differences across countries may be due to different clinical characteristics and differences in healthcare systems.