Chlorogenic acid inhibits trimethylamine-<i>N</i>-oxide formation and remodels intestinal microbiota to alleviate liver dysfunction in high <scp>l</scp>-carnitine feeding mice
Xiangnan Zhang, Lin Shi, Rui Chen, Yan Zhao, Daoyuan Ren, Xingbin Yang
Abstract
< 0.05). These findings suggest that CGA holds great potential to alleviate liver dysfunction induced by high L-carnitine ingestion. The beneficial effect might be attributed to the protection against TMAO formation and the improvement of the health-promoting gut microbiota, as well as the antioxidant and anti-inflammatory properties of CGA.
Topics & Concepts
CarnitineTrimethylamine N-oxideGut floraEndocrinologyLiver injuryAkkermansiaInternal medicineFirmicutesTrimethylamineChemistryIngestionBiologyBiochemistryMedicineLactobacillusFermentation16S ribosomal RNAGeneGut microbiota and healthPharmacological Effects of Natural CompoundsDiet and metabolism studies