Investigation of Novel Quinoline–Thiazole Derivatives as Antimicrobial Agents: <i>In Vitro</i> and <i>In Silico</i> Approaches
Asaf Evrim Evren, Abdullah Burak Karaduman, Begüm Nurpelin Sağlık, Yusuf Özkay, Leyla Yurttaş
Abstract
can be used alone for special patients who are suffering from fungal infections in addition to the primer disease.
Topics & Concepts
LanosterolPharmacophoreAntimicrobialQuinolineCytotoxicityIn silicoThiazoleDocking (animal)ChemistryDNA gyraseMoietyCombinatorial chemistryStereochemistryLipinski's rule of fiveActive siteEnzymeIn vitroBiochemistryOrganic chemistryMedicineEscherichia coliCholesterolSterolNursingGeneCancer therapeutics and mechanismsSynthesis and biological activitySynthesis and Biological Evaluation