Chemo- and regioselective defluorinative annulation of (trifluoromethyl)alkenes with pyrazolones: synthesis and insecticidal activity of 6-fluoro-1,4-dihydropyrano[2,3-<i>c</i>]pyrazoles
Chengxi Li, Hengyuan Li, Guangkai Yao, Xianghui Liang, Chen Zhao, Hanhong Xu, Huanfeng Jiang, Chuanle Zhu
Abstract
The chemo- and regioselective defluorinative [3 + 3] annulation of (trifluoromethyl)alkenes and pyrazolones gives useful 6-fluoro-1,4-dihydropyrano[2,3- c ]pyrazoles.
Topics & Concepts
PyrazolonesChemistryAnnulationRegioselectivityTrifluoromethylMedicinal chemistryStereochemistryOrganic chemistryCatalysisAlkylFluorine in Organic ChemistrySynthesis and Reactions of Organic CompoundsSynthesis and Biological Evaluation