Tuning intramolecular charge transfer and spin–orbit coupling of AIE-active type-I photosensitizers for photodynamic therapy
Ravinder Singh, Deng‐Gao Chen, Chun-Hsiang Wang, Chi-Chi Wu, Chao‐Hsien Hsu, Chi-Hua Wu, Tai-Ying Lai, Pi‐Tai Chou, Chao‐Tsen Chen
Abstract
), revealing its excellent diffusion capability in both lysosomal and mitochondrial organelles with low dark toxicity, high cytotoxicity under white-light and remarkable PDT efficiency. Our study has thus elucidated a rationally designed strategy at the molecular level to fine-tune ICT and SOC features for the advance of AIE-active type-I ROS PSs, opening a new avenue for cancer treatment and image-guided therapy.
Topics & Concepts
Intramolecular forcePhotodynamic therapyCoupling (piping)Spin–orbit interactionCharge (physics)Materials sciencePhotochemistryPhotosensitizerSpin (aerodynamics)OptoelectronicsChemistryPhysicsStereochemistryCondensed matter physicsOrganic chemistryMetallurgyThermodynamicsQuantum mechanicsNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials