Nanocubosomal based <i>in situ</i> gel loaded with natamycin for ocular fungal diseases: development, optimization, <i>in-vitro</i> , and <i>in-vivo</i> assessment
Khaled M. Hosny, Waleed Y. Rizg, Hala M. Alkhalidi, Walaa A. Abualsunun, Rana B. Bakhaidar, Alshaimaa M. Almehmady, Adel F. Alghaith, Sultan Alshehri, Amani M. El Sisi
Abstract
ocular irritation test proved that the optimum formulation is less irritating than a commercial formulation of NT. This further implies that the developed formulation produces less ocular irritation and can reduce the required frequency of administration.
Topics & Concepts
NatamycinAntifungalIn vivoIrritationPermeationLimitingSolubilityBroad spectrumIn vitroEye irritationMaterials scienceFungal keratitisDermatologyMedicineChemistryKeratitisCombinatorial chemistryBiologyOrganic chemistryPathologyBiochemistryMembraneBiotechnologyImmunologyEngineeringMechanical engineeringOcular Surface and Contact LensOcular Infections and TreatmentsCorneal Surgery and Treatments