Anti-Parkinson’s Activity of <i>Tribulus terrestris</i> via Modulation of AChE, α-Synuclein, TNF-α, and IL-1β
Uzma Saleem, Zunera Chauhdary, Zohaib Raza, Shahid Shah, Mahmood Ur Rahman, Parwasha Zaib, Bashir Ahmad
Abstract
< 0.05) decreased the level of acetylcholinesterase. RT-PCR results are showing down-regulation in the mRNA expression levels of IL-1β, α -synuclein, TNF-α, and AChE in TTME-treated groups compared to the disease control group, indicating neuroprotection. It is concluded that TTME has potential to ameliorate the symptoms of Parkinson's disease.
Topics & Concepts
AcetylcholinesteraseAchéTribulus terrestrisPharmacologyAntioxidantNeuroprotectionChemistryHaloperidolIn vivoInternal medicineEndocrinologyGlutathioneMedicineBiologyBiochemistryEnzymePathologyDopamineTraditional Chinese medicineAlternative medicineBiotechnologyCholinesterase and Neurodegenerative DiseasesMedicinal Plants and NeuroprotectionPhytochemicals and Antioxidant Activities