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Rh(<scp>iii</scp>)-catalyzed simultaneous [3 + 3]/[5 + 1] annulation of 1-arylpyrazolidinones with<i>gem</i>-difluorocyclopropenes leading to fluorinated pyridopyrimidinone derivatives

Mengyang Shen, Hao Li, Xinying Zhang, Xuesen Fan

2022Organic Chemistry Frontiers31 citationsDOI

Abstract

Presented herein is an efficient and concise synthesis of fluorinated pyridopyrimidinone derivatives through formal [3 + 3]/[5 + 1] annulation of 1-arylpyrazolidinones with gem -difluorocyclopropenes.

Topics & Concepts

AnnulationChemistryCatalysisCombinatorial chemistryMedicinal chemistryOrganic chemistryFluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods
Rh(<scp>iii</scp>)-catalyzed simultaneous [3 + 3]/[5 + 1] annulation of 1-arylpyrazolidinones with<i>gem</i>-difluorocyclopropenes leading to fluorinated pyridopyrimidinone derivatives | Litcius