Iron-catalyzed synthesis of N-heterocycles via intermolecular and intramolecular cyclization reactions: A review
Maria Sohail, Muhammad Bılal, Tahir Maqbool, Nasır Rasool, Muhammad Ammar, Sajid Mahmood, Ayesha Malik, Muhammad Zubair, Ghulam Abbas Ashraf
Abstract
Small N-heterocyclic molecules are important scaffolds in the pharmaceutical industry and most FDA-approved drugs are nitrogen-containing heterocycles. Chemists try to employ iron-based catalysts for organic transformations due to their abundance, economic, easily accessible and environment-friendly behaviour. N-heterocycles are synthesized by the cyclization reactions. This review covered the synthesis of N-heterocycles by employing iron-based catalysts via intermolecular or intramolecular cyclizations.
Topics & Concepts
ChemistryIntramolecular forceIntermolecular forceCatalysisCombinatorial chemistryEnvironmentally friendlyOrganic synthesisOrganic chemistryMoleculeEcologyBiologyCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions