Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo
Li Teng, Yue Shen, Yuhan QU, Longfei Yang, Yuting YANG, Xi JIAN, Shengli FAN, Lele Zhang, Qiang Fu
Topics & Concepts
InflammationChondrocyteOsteoarthritisMAPK/ERK pathwayIn vivoNitric oxideApoptosisChemistryAggrecanNitric oxide synthaseKinaseNF-κBPharmacologyADAMTSMatrix metalloproteinaseCartilageSignal transductionCancer researchThrombospondinMetalloproteinaseMedicineImmunologyInternal medicineIn vitroBiochemistryBiologyPathologyAnatomyBiotechnologyArticular cartilageAlternative medicineOsteoarthritis Treatment and MechanismsNatural product bioactivities and synthesisInflammatory mediators and NSAID effects