Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins
Milagros Pereira Luppi, Maite Azcorra, Giuliana Caronia-Brown, Jean‐François Poulin, Zachary Gaertner, Serafin Gatica, Oscar Andrés Moreno-Ramos, Navid Nouri, Marilyn Dubois, Yongchao Ma, Charu Ramakrishnan, Lief E. Fenno, Yoon-Seok Kim, Karl Deisseroth, Francesca Cicchetti, Daniel A. Dombeck, Rajeshwar Awatramani
Abstract
neurons project to the medial, ventral, and caudal striatum and respond to rewards. Moreover, we show that this adult division is encoded early in development. Overall, our work demonstrates a dual origin of the SNc that results in DA neuron cohorts with distinct molecular profiles, projections, and functions.
Topics & Concepts
Substantia nigraEmbryonic stem cellDopamineBiologyNeuroscienceExpression (computer science)MidbrainAnatomyGeneticsDopaminergicGeneCentral nervous systemComputer scienceProgramming languageNeurogenesis and neuroplasticity mechanismsGenetics, Aging, and Longevity in Model OrganismsCongenital heart defects research