Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation
Chenggong Sun, Xiao Li, Qiuli Teng, Xihan Liu, Li Song, Helgi B. Schiöth, Huan Wu, Xinyue Ma, Zhaoyang Zhang, Changjian Qi, H. C. Zhang, Kun Song, Qing Zhang, Beihua Kong
Abstract
Our study demonstrated the essential role of histone and RAD51 lactylation in HR repair and platinum resistance. It also identified a potential therapeutic strategy to overcome platinum resistance and improve prognosis in ovarian cancer.
Topics & Concepts
Ovarian cancerHistoneCancer researchRAD51PlatinumMedicineInternal medicineOncologyChemistryBiologyCancerBiochemistryDNA damageGeneDNACatalysisRNA modifications and cancerCancer-related molecular mechanisms researchMicroRNA in disease regulation