Global Metabolomic Profiling of Host Red Blood Cells Infected with Babesia divergens Reveals Novel Antiparasitic Target Pathways
Divya Beri, Manpreet Singh, Marilis Rodriguez, Naman Goyal, Giselle Rasquinha, Yunfeng Liu, Xiuli An, Karina Yazdanbakhsh, Cheryl A. Lobo
Abstract
Human babesiosis is caused by apicomplexan parasites of the Babesia genus and is associated with transfusion-transmitted illness and relapsing disease in immunosuppressed populations. Through its continuous cycles of invasion, proliferation, and egress, B. divergens radically changes the metabolic environment of the host red blood cell, allowing us opportunities to study potential chemical vulnerabilities that can be targeted by drugs.
Topics & Concepts
MetabolomicsBiologyParasite hostingMetabolic pathwayMetabolomeHost (biology)Intracellular parasiteLipid metabolismCell biologyMetabolismBiochemistryGeneticsBioinformaticsIntracellularComputer scienceWorld Wide WebVector-borne infectious diseasesMalaria Research and ControlMosquito-borne diseases and control