Dental manifestations of hypophosphatasia in children and the effects of enzyme replacement therapy on dental status: A series of clinical cases
L. P. Kiselnikova, Elena Vislobokova, V. Yu. Voinova
Abstract
The most frequent dental signs of hypophosphatasia in children are premature loss of primary teeth, decrease in height of alveolar bone, and malocclusions. Enzyme replacement therapy with Asfotase alfa might be associated with stabilization of dental status.
Topics & Concepts
HypophosphatasiaMedicineEnzyme replacement therapyDentistryAlkaline phosphataseDental alveolusPediatricsInternal medicineEnzymeDiseaseBiochemistryChemistryAlkaline Phosphatase Research StudiesBone health and treatmentsBone and Joint Diseases