Impacts of the Plateau Environment on the Gut Microbiota and Blood Clinical Indexes in Han and Tibetan Individuals
Zhilong Jia, Xiaojing Zhao, Xiaoshuang Liu, Le Zhao, Qian Jia, Jinlong Shi, Xiao Xu, Lijun Hao, Zhenguo Xu, Qin Zhong, Kang Yu, Saijia Cui, Huining Chen, Jianying Guo, Xiang Li, Yang Han, Xinyu Song, Chenghui Zhao, Xiaochen Bo, Yaping Tian, Weidong Wang, Guotong Xie, Qiang Feng, Kunlun He
Abstract
The data presented in the present study demonstrate that the hypoxic plateau environment has a profound impact on the gut microbiota and blood clinical indexes in Han and Tibetan individuals. The plateau-changed signatures of the gut microbiota and blood clinical indexes were not restored to the nonplateau status in the Han cohorts, even when the individuals returned to the plain from the plateau for several months. Our study will improve the understanding of the great impact of hypoxic environments on the gut microbiota and blood clinical indexes as well as the adaptation mechanism and intervention targets for plateau adaptation.