Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2
J. Kempf, K. Knelles, B.A. Hersbach, David Petřík, Therese Riedemann, V. Bednarova, Aleksandar Janjic, T. Simon-Ebert, W. Enard, P. Smialowski, Miriam S Götz, G. Masserdotti
Abstract
(Cell Reports 36, 109409-1–109409-16.e1–e7; July 20, 2021) In the originally published version of this article, Figure 3G contained an incorrect number of biological replicates. The original and corrected figure appear here, and the corrected figure now appears with the paper online. This correction does not change the percentages reported in the text. The authors regret these errors.Figure 3Expression of neuronal markers in Ascl1 and Neurog2 iNs (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2Kempf et al.Cell ReportsJuly 20, 2021In BriefKempf et al. show that Ascl1 and Neurog2 elicit initially divergent transcriptional programs in spinal cord astrocytes converging later to a V2 interneuron-like state, according to their developmental role and patterning cues in astrocytes. Patch-seq analysis reveals the heterogeneity of fate conversion with little correlation between transcriptome and electrophysiological properties. Full-Text PDF Open Access