Antibacterial Activity of Photoactive Silk Fibroin/Cellulose Acetate Blend Nanofibrous Membranes against <i>Escherichia coli</i>
Shixiong Yi, Yuehan Wu, Yuansong Zhang, Yushan Zou, Fangyin Dai, Yang Si
Abstract
Creating photoactive nanofibrous membranes for effective antibacterial activity is highly desired for healthy living, yet it still remains a great challenge. Herein, we present a scalable methodology to prepare anthraquinone-2-carboxylic acid grafted silk fibroin/cellulose acetate blend nanofibrous membranes (G-SF/CA BNM) by combining green biomass materials and electrospinning, which could produce reactive oxygen species (ROS) under UVA irradiation. The resultant G-SF/CA BNMs exhibited integrated properties of ultrathin fiber diameter (154 nm), larger surface area (11.25 m2 g–1), good mechanical properties, robust photoactive activity, and high bactericidal efficiency (99.9999% contact-killing). The fabrication of such fascinating materials may provide new insights into the design and development of photoactive nanofibrous membranes for antibacterial application.