Glycolipids from the gut symbiont <i>Bacteroides fragilis</i> are agonists for natural killer T cells and induce their regulatory differentiation
Garth Cameron, Tram Anh Thi Nguyen, Marcin Ciula, Spencer J. Williams, Dale I. Godfrey
Abstract
derived NKT cell agonists may have broad immunoregulatory activity, providing insight into the mechanisms influencing immune tolerance to commensal bacteria and highlighting a potential means to manipulate NKT cell function for therapeutic benefit.
Topics & Concepts
Natural killer T cellBacteroides fragilisCD1DBiologyImmune systemAntigenT-cell receptorGlycolipidT cellAntigen-presenting cellCell biologyImmunologyMicrobiologyAntibioticsImmune Cell Function and InteractionClostridium difficile and Clostridium perfringens researchGut microbiota and health