Effect of resveratrol on insulin action in primary myotubes from lean individuals and individuals with severe obesity
Sanghee Park, Filip Jevtovic, Polina Krassovskaia, Alec Chaves, Donghai Zheng, Jonas T. Treebak, Joseph A. Houmard
Abstract
A physiologically relevant dose of resveratrol increases insulin-stimulated glucose oxidation and glycogen synthesis in myotubes from individuals with severe obesity. Furthermore, resveratrol improved insulin signal transduction in myotubes from lean individuals but not from individuals with obesity. Activation of AMPK plays a role in resveratrol-induced improvements in glucose metabolism in individuals with severe obesity.
Topics & Concepts
ResveratrolMyogenesisAction (physics)ObesityInsulinInternal medicineEndocrinologyMedicinePrimary (astronomy)PsychologyPharmacologyMyocyteAstronomyPhysicsQuantum mechanicsSirtuins and Resveratrol in MedicineAdipose Tissue and MetabolismBiochemical effects in animals