Atroposelective synthesis of N–N axially chiral pyrrolyl(aza)-quinolinone by <i>de novo</i> ring formation
Qiwen Huang, Yanze Li, Cun Yang, Wendan Wu, Jingjie Hai, Xinyao Li
Abstract
A chiral phosphoric acid-catalyzed Paal–Knorr reaction was achieved for constructing axially chiral pyrrolyl(aza)quinolinones with ‘6–5’-membered rings as a new family member of N–N atropisomers.
Topics & Concepts
AtropisomerChemistryAxial symmetryPhosphoric acidRing (chemistry)StereochemistryCombinatorial chemistryOrganic chemistryStructural engineeringEngineeringAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityBiological Activity of Diterpenoids and Biflavonoids