PDE5 inhibition improves cardiac morphology and function in SHR by reducing NHE1 activity: Repurposing Sildenafil for the treatment of hypertensive cardiac hypertrophy
Daiana S. Escudero, María Soledad Brea, Claudia I. Caldiz, María E. Amarillo, Jorge Oswaldo Aranda, Enrique Leo Portiansky, Néstor G. Pérez, Romina G. Díaz
Topics & Concepts
SildenafilcGMP-specific phosphodiesterase type 5RepurposingInternal medicinePhosphodiesteraseProtein kinase ACardiac hypertrophyMedicineMyocardial hypertrophyCardiac function curvePharmacologyEndocrinologyCardiologyMuscle hypertrophyChemistryKinaseBiologyEnzymeHeart failureBiochemistryEcologyPhosphodiesterase function and regulationRenin-Angiotensin System StudiesHeart Failure Treatment and Management