Rhodium-catalyzed diastereoselective synthesis of highly substituted morpholines from nitrogen-tethered allenols
Azim Ziyaei Halimehjani, Bernhard Breit
Abstract
an atom-economic pathway with high to excellent yields, diastereo- and enantioselectivities (up to 99% yield, up to >99 : 1 dr and up to >99.9 ee). The utilities of the synthesized morpholines in ozonolysis, hydration, metathesis and epoxidation reactions were also investigated.
Topics & Concepts
RhodiumCatalysisChemistryNitrogenCombinatorial chemistryStereochemistryOrganic chemistryCyclopropane Reaction MechanismsAsymmetric Hydrogenation and CatalysisSynthetic Organic Chemistry Methods