Rational design of flexible microneedles coupled with CaO<sub>2</sub>@PDA-loaded nanofiber films for skin wound healing on diabetic rats
Zhiyong Zeng, Guohua Jiang, Yanfang Sun, Uladzislau E. Aharodnikau, Khaydar E. Yunusov, Xiaofei Gao, Tianqi Liu, Sergey O. Solomevich
Abstract
@PDA nanoparticles demonstrated a high level of CD31 and low level of TNF-α, leading to accelerated diabetic skin-wound closure. These distinctive features demonstrate that our microneedle system can be a facile candidate for efficient wound healing in patients with diabetes and may be applied in various biomedical fields.
Topics & Concepts
NanofiberBiomedical engineeringPolycaprolactoneWound healingGelatinTransdermalMetforminWound dressingPenetration (warfare)Materials scienceDiabetes mellitusMedicinePharmacologyChemistryNanotechnologySurgeryComposite materialPolymerOperations researchEndocrinologyBiochemistryEngineeringWound Healing and TreatmentsAdvancements in Transdermal Drug DeliveryDiabetic Foot Ulcer Assessment and Management