β<sub>2</sub>-Adrenergic agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint mean power output but not muscle force during 11 weeks of resistance training in young men
Søren Jessen, Søren Reitelseder, Anders Kalsen, Michael Kreiberg, Johan Onslev, Anders Gad, Niels Ørtenblad, Vibeke Backer, Lars Holm, Jens Bangsbo, Morten Hostrup
Abstract
-agonist salbutamol induces muscle fiber isoform transition from myosin-heavy-chain (MHC)-I toward MHCIIa and augments hypertrophy of MHCIIa fibers during a period of resistance training. Compared with placebo, salbutamol enhanced sprint mean power output, whereas peak power output and measures of muscle strength increased similarly during the resistance training period despite augmented hypertrophy with salbutamol. Thus, salbutamol is a muscle anabolic drug that can enhance sprint ability adaptations to resistance training.
Topics & Concepts
SalbutamolAgonistSprintMuscle hypertrophyResistance trainingInternal medicineEndocrinologyMedicinePrazosinAdrenergic agonistAnesthesiaCardiologyPhysical therapyAntagonistReceptorAsthmaPharmacological Effects and AssaysSports Performance and TrainingMuscle metabolism and nutrition