TAM-derived extracellular vesicles containing microRNA-29a-3p explain the deterioration of ovarian cancer
Lili Lu, Wanwen Ling, Zhengyi Ruan
Abstract
. Taken together, the current studies highlight the FOXO3-AKT/GSK3β pathway and the mechanism by which TAM-derived exosomal miR-29a-3p enhances the expression of PD-L1 to facilitate OC cell proliferation and immune escape.
Topics & Concepts
Extracellular vesiclesOvarian cancermicroRNAMicrovesiclesCancer researchExtracellularChemistryCancerVesicleCell biologyBiologyMedicineInternal medicineBiochemistryGeneMembraneExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases