<i>In Vitro</i> Antifungal Activity of Manogepix and Other Antifungal Agents against South African <i>Candida auris</i> Isolates from Bloodstream Infections
Tsidiso G. Maphanga, Ruth Mpembe, Serisha D. Naicker, Nelesh P. Govender, for GERMS-SA
Abstract
Since C. auris was first detected in South Africa in 2009, health care-associated transmission events and large outbreaks have led to this pathogen accounting for more than 1 in 10 cases of candidemia. A large proportion of South African C. auris isolates are highly resistant to fluconazole but variably resistant to amphotericin B and echinocandins.
Topics & Concepts
Candida aurisAntifungalMicrobiologyBloodstream infectionFluconazoleBiologyIn vitroEchinocandinsMedicineCaspofunginGeneticsAntifungal resistance and susceptibilityHerbal Medicine Research StudiesFungal Infections and Studies