Expanding organofluorine chemical space: the design of chiral fluorinated isosteres enabled by I(<scp>i</scp>)/I(<scp>iii</scp>) catalysis
Stephanie Meyer, Joel Häfliger, Ryan Gilmour
Abstract
Short aliphatic groups are prevalent in bioactive small molecules and play an essential role in regulating physicochemistry and molecular recognition phenomena.
Topics & Concepts
CatalysisChemical spaceChemistryMoleculeSmall moleculeCombinatorial chemistryOrganic chemistryStereochemistryBiochemistryDrug discoveryFluorine in Organic ChemistryChemical Synthesis and AnalysisAsymmetric Synthesis and Catalysis