B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response
Huoqun Gan, Tian Shen, Daniel P. Chupp, Julia R. Taylor, Helia N. Sanchez, Xin Li, Zhenming Xu, Hong Zan, Paolo Casali
Abstract
, or allosteric Sirt1 enhancement by SRT1720 repressed AID expression and CSR/SHM. By deacetylating histone and nonhistone proteins (Dnmt1 and NF-κB p65), Sirt1 transduces metabolic cues into epigenetic changes to play an important B cell-intrinsic role in modulating antibody and autoantibody responses.
Topics & Concepts
EpigeneticsHistoneEpigenetic regulation of neurogenesisHistone methyltransferaseGene expressionAntibodyCellCell biologyChemistryBiologyBiochemistryGeneticsGeneSirtuins and Resveratrol in MedicineImmune Cell Function and InteractionPARP inhibition in cancer therapy