Diet-induced obesity promotes infection by impairment of the innate antimicrobial defense function of dermal adipocyte progenitors
Ling‐juan Zhang, Christian F. Guerrero‐Juarez, Stella Chen, Xiaowei Zhang, Meimei Yin, Fengwu Li, Shuai Wu, Joyce Chen, Min Li, Yingzi Liu, Shang I. Brian Jiang, Tissa Hata, Maksim V. Plikus, Richard L. Gallo
Abstract
skin infection. Together, these results explain how obesity promotes dysfunction of the antimicrobial function of reactive dermal adipogenesis and identifies potential therapeutic targets to manage skin infection associated with obesity.
Topics & Concepts
AdipocyteInnate immune systemProgenitor cellAntimicrobialFunction (biology)ImmunologyObesityMedicineBiologyCell biologyAdipose tissueStem cellInternal medicineMicrobiologyImmune systemAdipokines, Inflammation, and Metabolic DiseasesDermatology and Skin DiseasesPsoriasis: Treatment and Pathogenesis