Copper-catalyzed direct synthesis of 3-methylene-2-arylisoindolin-1-ones with calcium carbide as a surrogate of gaseous acetylene
Jianglong Wu, Yinfeng Ma, Yan Wang, Chenyu Wang, Hui Luo, Dianjun Li, Jinhui Yang
Abstract
A novel strategy for the synthesis of 3-methyleneisoindolin-1-ones through Sonogashira reactions using calcium carbide was reported. This is a green and sustainable development of synthesis method.
Topics & Concepts
Calcium carbideAcetyleneSonogashira couplingCatalysisChemistryMethyleneCopperCombinatorial chemistryCalciumCarbideOrganic chemistryPalladiumSynthesis and Characterization of PyrrolesSynthesis and pharmacology of benzodiazepine derivativesFluorine in Organic Chemistry