Caspases Switch off the m <sup>6</sup> A RNA Modification Pathway to Foster the Replication of a Ubiquitous Human Tumor Virus
Kun Zhang, Yucheng Zhang, Yunash Maharjan, Febri Gunawan Sugiokto, Jun Wan, Renfeng Li
Abstract
The discovery of an N 6 -methyladenosine (m 6 A) RNA modification pathway has fundamentally altered our understanding of the central dogma of molecular biology. This pathway is controlled by methyltransferases (writers), demethylases (erasers), and specific m 6 A binding proteins (readers).
Topics & Concepts
BiologyRNACell biologyViral replicationCaspaseVirusGeneticsGeneProgrammed cell deathApoptosisRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research