Exercise-mediated alteration of hippocampal Dicer mRNA and miRNAs is associated with lower BACE1 gene expression and Aβ<sup>1-42</sup> in female 3xTg-AD mice
Cory M. Dungan, Taylor R. Valentino, Ivan J. Vechetti, Christopher J. Zdunek, Michael P. Murphy, Ai‐Ling Lin, John J. McCarthy, Charlotte A. Peterson
Abstract
Previous studies have outlined the beneficial effects of exercise on lowering BACE1 expression and reducing Aβ plaques. This study extends upon the work of others by outlining a new potential mechanism by which exercise elicits beneficial effects on Alzheimer's disease pathology, specifically through modulation of Dicer and miRNA expression. This is the first study to examine Dicer and miRNA expression in the hippocampus of the 3xTg model within the context of exercise.
Topics & Concepts
DicermicroRNAGene expressionHippocampal formationNeuroscienceBiologyRegulation of gene expressionGeneGeneticsTransfectionSmall interfering RNAAlzheimer's disease research and treatmentsMicroRNA in disease regulationNeurogenesis and neuroplasticity mechanisms