Catechols: a new class of carbonic anhydrase inhibitors
Katia D’Ambrosio, Simone Carradori, Stefania Cesa, Andrea Angeli, Simona Maria Monti, Claudiu T. Supuran, Giuseppina De Simone
Abstract
Catechols adopt a peculiar binding mode to the CA active site which involves both the zinc bound water molecule and the “deep water”.
Topics & Concepts
Carbonic anhydraseChemistryCarbonic anhydrase IIMoleculeZincBinding siteStereochemistryEnzymeCombinatorial chemistryBiochemistryBiophysicsOrganic chemistryBiologyEnzyme function and inhibitionSynthesis and Catalytic ReactionsCholinesterase and Neurodegenerative Diseases