Progress on the roles of MEF2C in neuropsychiatric diseases
Zhikun Zhang, Yongxiang Zhao
Abstract
Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-BOX family, is involved in embryonic brain development, neuronal formation and differentiation, as well as in the growth and pruning of axons and dendrites. MEF2C is also involved in the development of various neuropsychiatric disorders, such as autism spectrum disorders (ASD), epilepsy, schizophrenia and Alzheimer's disease (AD). Here, we review the relationship between MEF2C and neuropsychiatric disorders, and provide further insights into the mechanism of these diseases.
Topics & Concepts
MEF2CNeuroscienceSchizophrenia (object-oriented programming)Mef2EpilepsyDiseaseDrug repositioningAutismMechanism (biology)Transcription factorMedicinePsychiatryEnhancerPsychologyBiologyGeneticsDrugInternal medicineGenePhilosophyEpistemologyGenetics and Neurodevelopmental DisordersEpigenetics and DNA MethylationCongenital heart defects research