Impact of net charge, targeting ligand amount and mRNA modification on the uptake, intracellular routing and the transfection efficiency of mRNA lipopolyplexes in dendritic cells
Christophe Delehedde, Ivan Ciganek, Nathalie Rameix, Nabila Laroui, Cristine Gonçalves, Luc Even, Patrick Midoux, Chantal Pichon
Topics & Concepts
ChemistryMannoseTransfectionBiophysicsSmall interfering RNAMessenger RNACationic polymerizationIntracellularCell biologyMolecular biologyBiochemistryBiologyGeneOrganic chemistryRNA Interference and Gene DeliveryRNA Research and SplicingRNA and protein synthesis mechanisms