Asymmetric chromosome segregation and cell division in DNA damage-induced bacterial filaments
Suchitha Raghunathan, Afroze Chimthanawala, Sandeep Krishna, Anthony G. Vecchiarelli, Anjana Badrinarayanan
Abstract
The DNA damage response and cell division checkpoints have been well studied in several bacterial model systems, but how cells exit such a checkpoint to restart wild-type growth is unclear. This study highlights a central function for asymmetric division in mediating cellular recovery from DNA damage.
Topics & Concepts
BiologyCell divisionG2-M DNA damage checkpointDNA damageCell biologyChromosome segregationDNADivision (mathematics)DNA repairFunction (biology)ChromosomeGeneticsCell cycleCellCell cycle checkpointGeneArithmeticMathematicsBacterial Genetics and BiotechnologyBacteriophages and microbial interactionsDNA Repair Mechanisms